Detection of genotyping errors and pseudo-SNPs via deviations from Hardy-Weinberg equilibrium
نویسندگان
چکیده
منابع مشابه
Significant deviations from Hardy-Weinberg equilibrium caused by low levels of microsatellite genotyping errors.
Microsatellite genotyping from samples with varying quality can result in an uneven distribution of errors. Previous studies reporting error rates have focused on estimating the effects of both randomly distributed and locus-specific errors. Sample-specific errors, however, can also significantly affect results in population studies despite a large sample size. From two studies including six mi...
متن کاملDeparture from Hardy Weinberg Equilibrium and Genotyping Error
Objective: Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation or genotyping error. We searched for specific characteristics of HWE-departure due to genotyping error. Methods: Genotypes of a random set of genetic variants were obtained from the Exome Aggregation Consortium...
متن کاملDeviations from hardy-weinberg equilibrium in parental and unaffected sibling genotype data.
BACKGROUND Genotyping error can increase both type I and II errors. In order to elucidate potential genotyping errors, data quality control often includes testing genotype data for deviations from Hardy-Weinberg Equilibrium (HWE). METHODS The Hardy-Weinberg Disequilibrium (HWD) coefficient and the ability to reject the null hypothesis of HWE were calculated analytically for genotype data from...
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Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2005
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.20086